In the ever-evolving world of fitness and weight loss, GLP-1 receptor agonists like semaglutide (Ozempic®, Wegovy®) and tirzepatide (Mounjaro®, Zepbound®) have become major players. While these medications were initially designed for managing type 2 diabetes, they’ve gained massive popularity for their ability to support weight loss by reducing hunger and improving metabolic function. But before you consider these medications as a shortcut to fat loss, it's crucial to understand the latest FDA updates, the risks of compounded versions, and how to approach weight loss the smart way—with proper training, nutrition, and sustainable lifestyle changes. At BlastFitness.com, we believe in evidence-based fitness strategies and long-term health over quick fixes. Let’s break down the key takeaways.
GLP-1 Supply Issues: What’s Changing?
For the past few years, demand for GLP-1 weight loss drugs has surged, leading to supply shortages. However, the FDA has now confirmed that semaglutide supply issues have been resolved (as of February 21, 2025). Tirzepatide shortages were officially resolved in December 2024. This means that patients and healthcare providers can now access these medications more reliably, reducing the need for compounded versions, which can come with serious risks. However, as pharmacies restock, localized supply shortages may still occur for a short period.
Why You Should Be Cautious About Compounded GLP-1 Drugs
When FDA-approved versions of semaglutide and tirzepatide were in short supply, some people turned to compounded versions made by specialized pharmacies. However, compounded medications are not FDA-approved and come with risks, such as inconsistent dosing, leading to ineffective results or dangerous side effects. Potential contamination or lower-quality ingredients. Use of unauthorized salt forms (like semaglutide sodium), which have not been proven safe or effective. The FDA has received 455+ reports of adverse effects related to compounded semaglutide and 320+ reports related to compounded tirzepatide. Now that supply issues are being resolved, it’s time to transition back to FDA-approved medications if you’re using a compounded version.
How to Use GLP-1 Medications the Smart Way
If you’re thinking about incorporating GLP-1 medications into your weight loss plan, they should be part of a well-rounded fitness and nutrition strategy—not a replacement for good habits. Here’s how to do it right:
1. Prioritize Strength Training & Muscle Preservation
GLP-1 drugs can reduce hunger, which means some people lose muscle along with fat if they aren’t resistance training. Don’t make that mistake. Strength training at least 3-5 times per week ensures that you maintain muscle mass and metabolic health while losing fat.
2. Fuel Your Body with High-Quality Protein
Since GLP-1 drugs can reduce appetite, it’s easy to under-eat protein, leading to muscle loss and a sluggish metabolism. Prioritize lean proteins like chicken, turkey, and fish, eggs and egg whites, Greek yogurt and cottage cheese, plant-based sources like lentils and tofu. Aim for at least 0.8-1.2g of protein per pound of body weight to keep your body fueled and strong.
3. Stay Hydrated and Manage Electrolytes
One common side effect of GLP-1 medications is dehydration due to nausea or reduced appetite. To stay on top of your hydration, drink at least half your body weight (lbs) in ounces of water daily. Add electrolytes to your routine, especially if you train intensely. Monitor your sodium, potassium, and magnesium levels to avoid muscle cramps and fatigue.
4. Move More Throughout the Day
NEAT (Non-Exercise Activity Thermogenesis) is one of the most underrated tools for fat loss. Whether or not you’re taking a GLP-1 medication, increasing your daily movement helps burn more calories without added stress on your body. Try taking 10,000+ steps daily. Using a standing desk. Doing light stretching or yoga between workouts.
5. Avoid Counterfeit & Illegally Marketed GLP-1 Drugs
The FDA has warned against counterfeit versions of Ozempic and similar drugs being sold online. These fake medications may contain the wrong active ingredients, no active ingredient at all, harmful additives that pose health risks. Always obtain your medications through a licensed healthcare provider and a state-licensed pharmacy.
Final Thoughts: The Best Weight Loss Strategy is a Sustainable One
GLP-1 medications can be a useful tool, but they should never be seen as a magic fix. The best weight loss strategy always includes strength training to preserve muscle and boost metabolism. High-protein nutrition to support recovery and fat loss. Hydration & electrolytes to maintain performance. Daily movement to keep your metabolism active. The FDA’s updates on semaglutide and tirzepatide availability mean that compounded versions are no longer necessary. If you’ve been using one, talk to your healthcare provider about switching back to an FDA-approved version. At BlastFitness.com, we’re here to help you navigate your weight loss journey with science-backed, practical strategies. Build strength. Fuel smart. Move daily. That’s the real formula for long-term success.
Also Read: FDA’s Warning on Unapproved GLP-1 Weight Loss Drugs